Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt

Akt activation is a hallmark of human cancers. Here we report a critical mechanism for regulation of Akt activity by the splicing kinase SRPK1, a downstream Akt target for transducing growth signals to regulate splicing. Surprisingly, we find that SRPK1 has a tumor suppressor function because ablati...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wang, Pingping, Zhou, Zhihong, Hu, Anchang, de Albuquerque, Claudio Ponte, Zhou, Yu, Hong, Lixin, Sierecki, Emma, Ajiro, Masahiko, Kruhlak, Michael, Harris, Curtis, Guan, Kunliang, Zheng, Zhi-Ming, Newton, Alexandra C., Sun, Peiqing, Zhou, Huilin, Fu, Xiang-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019712/
https://ncbi.nlm.nih.gov/pubmed/24703948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados