The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus

Pre-mRNA splicing is regulated by developmental and environmental cues, but little is known about how specific signals are transduced in mammalian cells to regulate this critical gene expression step. Here, we report massive reprogramming of alternative splicing in response to EGF signaling. By bloc...

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Hauptverfasser: Zhou, Zhihong, Qiu, Jinsong, Wen, Liu, Zhou, Yu, Plocinik, Ryan M., Li, Hairi, Hu, Qidong, Ghosh, Gourisanker, Adams, Joseph A., Rosenfeld, Michael G., Fu, Xiang-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418396/
https://ncbi.nlm.nih.gov/pubmed/22727668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.014
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