SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells

Cisplatin and other platinum-based compounds are frequently used to treat breast cancer, but their utility is severely compromised by drug resistance. Many genes dictating drug responsiveness are subject to pre-mRNA alternative splicing which is regulated by key kinases such as the serine-arginine p...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Wang, Cheng, Zhou, Zhihong, Subhramanyam, Charannya Sozheesvari, Cao, Qiong, Heng, Zealyn Shi Lin, Liu, Wen, Fu, Xiangdong, Hu, Qidong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253463/
https://ncbi.nlm.nih.gov/pubmed/32461560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0983-4
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