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PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth
PHLPP is a family of Ser/Thr protein phosphatases that contains PHLPP1 and PHLPP2 isoforms. We have shown previously that PHLPP functions as a tumor suppressor by negatively regulating Akt signaling in cancer cells. Here we report the identification of ribosomal protein S6 kinase 1 (S6K1) as a novel...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233022/ https://ncbi.nlm.nih.gov/pubmed/21986499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05799-11 |
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