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mTOR-Dependent Regulation of PHLPP Expression Controls the Rapamycin Sensitivity in Cancer Cells

PHLPP belongs to a novel family of protein phosphatases that serve as negative regulators of Akt. There are two isoforms, PHLPP1 and PHLPP2, identified in this family. Our previous studies indicated a tumor suppressor role of both PHLPP isoforms in colon cancer. Here we report that the expression of...

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Библиографические подробности
Главные авторы: Liu, Jianyu, Stevens, Payton D., Gao, Tianyan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057781/
https://ncbi.nlm.nih.gov/pubmed/21177869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183087
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