PHLPP is a Negative Regulator of RAF1 that Reduces Colorectal Cancer Cell Motility and Prevents Tumor Progression in Mice

BACKGROUND & AIMS: Hyperactivation of the RAS-RAF signaling pathway in colorectal tumors is associated with metastasis and poor outcomes of patients. Little is known about how RAS–RAF signaling is turned off once activated. We investigated how the pH domain and leucine-rich repeat protein phosph...

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Detalhes bibliográficos
Main Authors: Li, Xin, Stevens, Payton D., Liu, Jianyu, Yang, Haihua, Wang, Wei, Wang, Chi, Zeng, Zheng, Schmidt, Micheal D., Yang, Mike, Lee, Eun Y., Gao, Tianyan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992173/
https://ncbi.nlm.nih.gov/pubmed/24530606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.02.003
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