PHLPP is a Negative Regulator of RAF1 that Reduces Colorectal Cancer Cell Motility and Prevents Tumor Progression in Mice

BACKGROUND & AIMS: Hyperactivation of the RAS-RAF signaling pathway in colorectal tumors is associated with metastasis and poor outcomes of patients. Little is known about how RAS–RAF signaling is turned off once activated. We investigated how the pH domain and leucine-rich repeat protein phosph...

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Huvudupphovsmän: Li, Xin, Stevens, Payton D., Liu, Jianyu, Yang, Haihua, Wang, Wei, Wang, Chi, Zeng, Zheng, Schmidt, Micheal D., Yang, Mike, Lee, Eun Y., Gao, Tianyan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992173/
https://ncbi.nlm.nih.gov/pubmed/24530606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.02.003
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