PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart

RATIONALE: The recently discovered PHLPP-1 (PH domain leucine-rich repeat protein phosphatase-1) selectively dephosphorylates Akt at Ser473 and terminates Akt signaling in cancer cells. The regulatory role of PHLPP-1 in the heart has not been considered. OBJECTIVE: To test the hypothesis that blocka...

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Detalhes bibliográficos
Main Authors: Miyamoto, Shigeki, Purcell, Nicole H., Smith, Jeffrey M., Gao, Tianyan, Whittaker, Ross, Huang, Katherine, Castillo, Rene, Glembotski, Chris C., Sussman, Mark A., Newton, Alexandra C., Brown, Joan Heller
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957297/
https://ncbi.nlm.nih.gov/pubmed/20576936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.215020
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