Preclinical Characterization of Signal Transducer and Activator of Transcription 3 Small Molecule Inhibitors for Primary and Metastatic Brain Cancer Therapy

Signal transducer and activator of transcription 3 (STAT3) has been implicated as a hub for multiple oncogenic pathways. The constitutive activation of STAT3 is present in several cancers, including gliomas (GBMs), and is associated with poor therapeutic responses. Phosphorylation of STAT3 triggers...

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Autors principals: Assi, Hikmat H., Paran, Chris, VanderVeen, Nathan, Savakus, Jonathan, Doherty, Robert, Petruzzella, Emanuele, Hoeschele, James D., Appelman, Henry, Raptis, Leda, Mikkelsen, Tom, Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2014
Matèries:
Chemotherapy, Antibiotics, and Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019317/
https://ncbi.nlm.nih.gov/pubmed/24696041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214619
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