Adenovirus Binding to the Coxsackievirus and Adenovirus Receptor or Integrins Is Not Required To Elicit Brain Inflammation but Is Necessary To Transduce Specific Neural Cell Types

Intracranial administration of adenovirus vectors elicits rapid, capsid-mediated dose-dependent brain inflammation. The mechanisms through which adenovirus capsids trigger inflammation in the brain remain unknown. We determined whether adenovirus interaction with the primary and secondary cell surfa...

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Detalhes bibliográficos
Main Authors: Thomas, Clare E., Edwards, Penny, Wickham, Thomas J., Castro, Maria G., Lowenstein, Pedro R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136027/
https://ncbi.nlm.nih.gov/pubmed/11884569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.7.3452-3460.2002
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