Adenovirus Binding to the Coxsackievirus and Adenovirus Receptor or Integrins Is Not Required To Elicit Brain Inflammation but Is Necessary To Transduce Specific Neural Cell Types

Intracranial administration of adenovirus vectors elicits rapid, capsid-mediated dose-dependent brain inflammation. The mechanisms through which adenovirus capsids trigger inflammation in the brain remain unknown. We determined whether adenovirus interaction with the primary and secondary cell surfa...

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Bibliographische Detailangaben
Hauptverfasser: Thomas, Clare E., Edwards, Penny, Wickham, Thomas J., Castro, Maria G., Lowenstein, Pedro R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC136027/
https://ncbi.nlm.nih.gov/pubmed/11884569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.7.3452-3460.2002
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