An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

Recombinant adenoviruses (Ad) have become the vector system of choice for a variety of gene therapy applications. However, the utility of Ad vectors is limited due to the low efficiency of Ad-mediated gene transfer to cells expressing marginal levels of the coxsackievirus and adenovirus receptor (CA...

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Hlavní autoři: Dmitriev, Igor, Krasnykh, Victor, Miller, C. Ryan, Wang, Minghui, Kashentseva, Elena, Mikheeva, Galina, Belousova, Natalya, Curiel, David T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1998
Témata:
Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC110480/
https://ncbi.nlm.nih.gov/pubmed/9811704
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