An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

Recombinant adenoviruses (Ad) have become the vector system of choice for a variety of gene therapy applications. However, the utility of Ad vectors is limited due to the low efficiency of Ad-mediated gene transfer to cells expressing marginal levels of the coxsackievirus and adenovirus receptor (CA...

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Autores principales: Dmitriev, Igor, Krasnykh, Victor, Miller, C. Ryan, Wang, Minghui, Kashentseva, Elena, Mikheeva, Galina, Belousova, Natalya, Curiel, David T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC110480/
https://ncbi.nlm.nih.gov/pubmed/9811704
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