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An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

Recombinant adenoviruses (Ad) have become the vector system of choice for a variety of gene therapy applications. However, the utility of Ad vectors is limited due to the low efficiency of Ad-mediated gene transfer to cells expressing marginal levels of the coxsackievirus and adenovirus receptor (CA...

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Udgivet i:J Virol
Principais autores: Dmitriev, Igor, Krasnykh, Victor, Miller, C. Ryan, Wang, Minghui, Kashentseva, Elena, Mikheeva, Galina, Belousova, Natalya, Curiel, David T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110480/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.12.9706-9713.1998
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