Treatment with the 3-Ketoacyl-CoA Thiolase Inhibitor Trimetazidine Does Not Exacerbate Whole-Body Insulin Resistance in Obese Mice

There is a growing need to understand the underlying mechanisms involved in the progression of cardiovascular disease during obesity and diabetes. Although inhibition of fatty acid oxidation has been proposed as a novel approach to treat ischemic heart disease and heart failure, reduced muscle fatty...

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Detalhes bibliográficos
Main Authors: Ussher, John R., Keung, Wendy, Fillmore, Natasha, Koves, Timothy R., Mori, Jun, Zhang, Liyan, Lopaschuk, David G., Ilkayeva, Olga R., Wagg, Cory S., Jaswal, Jagdip S., Muoio, Deborah M., Lopaschuk, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Endocrine and Diabetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019316/
https://ncbi.nlm.nih.gov/pubmed/24700885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214197
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