Phosphoinositide-Dependent Kinase 1 and mTORC2 Synergistically Maintain Postnatal Heart Growth and Heart Function in Mice

The protein kinase Akt plays a critical role in heart function and is activated by phosphorylation of threonine 308 (T308) and serine 473 (S473). While phosphoinositide-dependent kinase 1 (PDK1) is responsible for Akt T308 phosphorylation, the identities of the kinases for Akt S473 phosphorylation i...

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Bibliografiske detaljer
Main Authors: Zhao, Xia, Lu, Shuangshuang, Nie, Junwei, Hu, Xiaoshan, Luo, Wen, Wu, Xiangqi, Liu, Hailang, Feng, Qiuting, Chang, Zai, Liu, Yaoqiu, Cao, Yunshan, Sun, Haixiang, Li, Xinli, Hu, Yali, Yang, Zhongzhou
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019065/
https://ncbi.nlm.nih.gov/pubmed/24662050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00144-14
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