Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

cGMP and cAMP-dependent protein kinases (PKG and PKA) are closely related homologs, and the cyclic nucleotide specificity of each kinase is crucial for keeping the two signaling pathways segregated, but the molecular mechanism of cyclic nucleotide selectivity is unknown. Here we report that the PKG...

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Detalhes bibliográficos
Main Authors: Huang, Gilbert Y., Kim, Jeong Joo, Reger, Albert S., Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E., Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W., Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W., Kim, Choel
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019043/
https://ncbi.nlm.nih.gov/pubmed/24239458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.021
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