The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits WT DNMT3A by Blocking its Ability to Form Active Tetramers

Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found in ~30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are heterozygous and alter R882 within the catalytic domain (most commonly R882H), suggesting the possibility of dominant negative cons...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Russler-Germain, David A., Spencer, David H., Young, Margaret A., Lamprecht, Tamara L., Miller, Christopher A., Fulton, Robert, Meyer, Matthew R., Erdmann-Gilmore, Petra, Townsend, R. Reid, Wilson, Richard K., Ley, Timothy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018976/
https://ncbi.nlm.nih.gov/pubmed/24656771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.02.010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky