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Small-Molecule Allosteric Activators of Sirtuins

The mammalian sirtuins (SIRT1–7) are NAD(+)-dependent lysine deacylases that play central roles in cell survival, inflammation, energy metabolism, and aging. Members of this family of enzymes are considered promising pharmaceutical targets for the treatment of age-related diseases including cancer,...

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Библиографические подробности
Главные авторы: Sinclair, David A., Guarente, Leonard
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018738/
https://ncbi.nlm.nih.gov/pubmed/24160699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010611-134657
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