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Small-Molecule Allosteric Activators of Sirtuins

The mammalian sirtuins (SIRT1–7) are NAD(+)-dependent lysine deacylases that play central roles in cell survival, inflammation, energy metabolism, and aging. Members of this family of enzymes are considered promising pharmaceutical targets for the treatment of age-related diseases including cancer,...

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Detalhes bibliográficos
Main Authors: Sinclair, David A., Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018738/
https://ncbi.nlm.nih.gov/pubmed/24160699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010611-134657
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