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Small-Molecule Allosteric Activators of Sirtuins
The mammalian sirtuins (SIRT1–7) are NAD(+)-dependent lysine deacylases that play central roles in cell survival, inflammation, energy metabolism, and aging. Members of this family of enzymes are considered promising pharmaceutical targets for the treatment of age-related diseases including cancer,...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018738/ https://ncbi.nlm.nih.gov/pubmed/24160699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010611-134657 |
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