Lin28 sustains early renal progenitors and induces Wilms tumor

Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final...

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Autori principali: Urbach, Achia, Yermalovich, Alena, Zhang, Jin, Spina, Catherine S., Zhu, Hao, Perez-Atayde, Antonio R., Shukrun, Rachel, Charlton, Jocelyn, Sebire, Neil, Mifsud, William, Dekel, Benjamin, Pritchard-Jones, Kathy, Daley, George Q.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018495/
https://ncbi.nlm.nih.gov/pubmed/24732380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.237149.113
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