Lin28 sustains early renal progenitors and induces Wilms tumor

Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Urbach, Achia, Yermalovich, Alena, Zhang, Jin, Spina, Catherine S., Zhu, Hao, Perez-Atayde, Antonio R., Shukrun, Rachel, Charlton, Jocelyn, Sebire, Neil, Mifsud, William, Dekel, Benjamin, Pritchard-Jones, Kathy, Daley, George Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018495/
https://ncbi.nlm.nih.gov/pubmed/24732380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.237149.113
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge