Lin28 sustains early renal progenitors and induces Wilms tumor

Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Urbach, Achia, Yermalovich, Alena, Zhang, Jin, Spina, Catherine S., Zhu, Hao, Perez-Atayde, Antonio R., Shukrun, Rachel, Charlton, Jocelyn, Sebire, Neil, Mifsud, William, Dekel, Benjamin, Pritchard-Jones, Kathy, Daley, George Q.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2014
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018495/
https://ncbi.nlm.nih.gov/pubmed/24732380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.237149.113
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