Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood

BACKGROUND: Wilms tumor is the most common pediatric renal malignancy and there is a clinical need for a molecular biomarker to assess treatment response and predict relapse. The known mutated genes in this tumor type show low mutation frequencies, whereas aberrant methylation at 11p15 is by far the...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Charlton, Jocelyn, Williams, Richard D, Weeks, Mark, Sebire, Neil J, Popov, Sergey, Vujanic, Gordan, Mifsud, William, Alcaide-German, Marisa, Butcher, Lee M, Beck, Stephan, Pritchard-Jones, Kathy
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310621/
https://ncbi.nlm.nih.gov/pubmed/25134821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0434-y
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