Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumour

BACKGROUND: Wilms tumours (WTs) are characterised by several hallmarks that suggest epimutations such as aberrant DNA methylation are involved in tumour progression: loss of imprinting at 11p15, lack of recurrent mutations and formation of nephrogenic rests (NRs), which are lesions of retained undif...

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Pubblicato in:Genome Med
Autori principali: Charlton, Jocelyn, Williams, Richard D, Sebire, Neil J, Popov, Sergey, Vujanic, Gordan, Chagtai, Tasnim, Alcaide-German, Marisa, Morris, Tiffany, Butcher, Lee M, Guilhamon, Paul, Beck, Stephan, Pritchard-Jones, Kathy
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354990/
https://ncbi.nlm.nih.gov/pubmed/25763109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0136-4
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