Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

[Image: see text] We report the development and characterization of compound 22 (MK-5046), a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3). In pharmacological testing using diet-induced obese mice, compound 22 caused mechanism-based, dose-dependent reductions in foo...

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Autors principals: Sebhat, Iyassu K., Franklin, Christopher, Lo, Michael M.-C., Chen, David, Jewell, James P., Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M., Guan, Xiao-Ming, Marsh, Donald J., Kosinski, Jennifer A., Metzger, Joseph M., Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R., Henderson, Alan J., Reitman, Marc L., Nargund, Ravi P., Wyvratt, Matthew J., Lin, Linus S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018145/
https://ncbi.nlm.nih.gov/pubmed/24900253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100196d
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