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Bisdionin C—A Rationally Designed, Submicromolar Inhibitor of Family 18 Chitinases

[Image: see text] Chitinases of the GH18 family play important roles in a variety of pathogenic organisms and have also been shown to be involved in human asthma progression, making these enzymes potential drug targets. While a number of potent GH18 chitinase inhibitors have been described, in gener...

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Detalhes bibliográficos
Main Authors: Schüttelkopf, Alexander W., Andersen, Ole A., Rao, Francesco V., Allwood, Matthew, Rush, Christina L., Eggleston, Ian M., van Aalten, Daan M. F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018065/
https://ncbi.nlm.nih.gov/pubmed/24900325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200008b
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