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Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin
Chitinase inhibitors have chemotherapeutic potential as fungicides, pesticides, and antiasthmatics. Argifin, a natural product cyclopentapeptide, competitively inhibits family 18 chitinases in the nanomolar to micromolar range and shows extensive substrate mimicry. In an attempt to map the active fr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3764403/ https://ncbi.nlm.nih.gov/pubmed/18355729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.02.015 |
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