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Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

Chitinase inhibitors have chemotherapeutic potential as fungicides, pesticides, and antiasthmatics. Argifin, a natural product cyclopentapeptide, competitively inhibits family 18 chitinases in the nanomolar to micromolar range and shows extensive substrate mimicry. In an attempt to map the active fr...

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Bibliografiske detaljer
Main Authors: Andersen, Ole A., Nathubhai, Amit, Dixon, Mark J., Eggleston, Ian M., van Aalten, Daan M.F.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764403/
https://ncbi.nlm.nih.gov/pubmed/18355729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.02.015
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