Effective and selective targeting of Ph(+) leukemia cells using a TORC1/2 kinase inhibitor

Targeting the mammalian target of rapamycin (mTOR) is a promising strategy for cancer therapy. However, the mTOR kinase functions in two complexes, TORC1 and TORC2, neither of which is fully inhibited by the allosteric inhibitor rapamycin or analogs. We compared rapamycin with the active-site TORC1/...

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Autors principals: Janes, Matthew R., Limon, Jose J., So, Lomon, Chen, Jing, Lim, Raymond J., Chavez, Melissa A., Vu, Collin, Lilly, Michael B., Mallya, Sharmila, Ong, S. Tiong, Marina, Konopleva, Martin, Michael B., Ren, Pingda, Liu, Yi, Rommel, Christian, Fruman, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017764/
https://ncbi.nlm.nih.gov/pubmed/20072130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2091
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