Effective and selective targeting of Ph(+) leukemia cells using a TORC1/2 kinase inhibitor

Targeting the mammalian target of rapamycin (mTOR) is a promising strategy for cancer therapy. However, the mTOR kinase functions in two complexes, TORC1 and TORC2, neither of which is fully inhibited by the allosteric inhibitor rapamycin or analogs. We compared rapamycin with the active-site TORC1/...

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Hlavní autoři: Janes, Matthew R., Limon, Jose J., So, Lomon, Chen, Jing, Lim, Raymond J., Chavez, Melissa A., Vu, Collin, Lilly, Michael B., Mallya, Sharmila, Ong, S. Tiong, Marina, Konopleva, Martin, Michael B., Ren, Pingda, Liu, Yi, Rommel, Christian, Fruman, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017764/
https://ncbi.nlm.nih.gov/pubmed/20072130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2091
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