Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear. In acute myeloid leukemia (AML), internal tandem duplication (ITD) of FLT3 at the juxtamembrane (JMD) and tyrosine kinase (TKD) domains (FLT3-ITD(+))...

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Detalhes bibliográficos
Main Authors: He, Bai-Liang, Shi, Xiangguo, Man, Cheuk Him, Ma, Alvin C. H., Ekker, Stephen C., Chow, Howard C. H., So, Chi Wai Eric, Choi, William W. L., Zhang, Wenqing, Zhang, Yiyue, Leung, Anskar Y. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017313/
https://ncbi.nlm.nih.gov/pubmed/24591202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-486688
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