Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear. In acute myeloid leukemia (AML), internal tandem duplication (ITD) of FLT3 at the juxtamembrane (JMD) and tyrosine kinase (TKD) domains (FLT3-ITD(+))...

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Sonraí Bibleagrafaíochta
Main Authors: He, Bai-Liang, Shi, Xiangguo, Man, Cheuk Him, Ma, Alvin C. H., Ekker, Stephen C., Chow, Howard C. H., So, Chi Wai Eric, Choi, William W. L., Zhang, Wenqing, Zhang, Yiyue, Leung, Anskar Y. H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2014
Ábhair:
Myeloid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017313/
https://ncbi.nlm.nih.gov/pubmed/24591202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-486688
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