Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear. In acute myeloid leukemia (AML), internal tandem duplication (ITD) of FLT3 at the juxtamembrane (JMD) and tyrosine kinase (TKD) domains (FLT3-ITD(+))...

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Hlavní autoři: He, Bai-Liang, Shi, Xiangguo, Man, Cheuk Him, Ma, Alvin C. H., Ekker, Stephen C., Chow, Howard C. H., So, Chi Wai Eric, Choi, William W. L., Zhang, Wenqing, Zhang, Yiyue, Leung, Anskar Y. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017313/
https://ncbi.nlm.nih.gov/pubmed/24591202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-486688
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