Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

FLT3 is a frequently mutated gene that is highly associated with a poor prognosis in acute myeloid leukemia (AML). Despite initially responding to FLT3 inhibitors, most patients eventually relapse with drug resistance. The mechanism by which resistance arises and the initial response to drug treatme...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Gebru, Melat T., Atkinson, Jennifer M., Young, Megan M., Zhang, Lijun, Tang, Zhenyuan, Liu, Zhenqiu, Lu, Pinyi, Dower, Christopher M., Chen, Longgui, Annageldiyev, Charyguly, Sharma, Arati, Imamura Kawasawa, Yuka, Zhao, Zhongming, Miller, Barbara A., Claxton, David F., Wang, Hong-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453151/
https://ncbi.nlm.nih.gov/pubmed/32396937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003124
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