Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

FLT3 is a frequently mutated gene that is highly associated with a poor prognosis in acute myeloid leukemia (AML). Despite initially responding to FLT3 inhibitors, most patients eventually relapse with drug resistance. The mechanism by which resistance arises and the initial response to drug treatme...

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發表在:Blood
Main Authors: Gebru, Melat T., Atkinson, Jennifer M., Young, Megan M., Zhang, Lijun, Tang, Zhenyuan, Liu, Zhenqiu, Lu, Pinyi, Dower, Christopher M., Chen, Longgui, Annageldiyev, Charyguly, Sharma, Arati, Imamura Kawasawa, Yuka, Zhao, Zhongming, Miller, Barbara A., Claxton, David F., Wang, Hong-Gang
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2020
主題:
Myeloid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453151/
https://ncbi.nlm.nih.gov/pubmed/32396937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003124
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