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Pyrrolysyl-tRNA Synthetase: an ordinary enzyme but an outstanding genetic code expansion tool
The genetic incorporation of the 22(nd) proteinogenic amino acid, pyrolysine (Pyl) at amber codon is achieved by the action of pyrrolysyl-tRNA synthetase (PylRS) together with its cognate tRNA(Pyl). Unlike most aminoacyl-tRNA synthetases, PylRS displays high substrate side chain promiscuity, low sel...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4016821/ https://ncbi.nlm.nih.gov/pubmed/24631543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.03.002 |
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