Pyrrolysyl-tRNA Synthetase: an ordinary enzyme but an outstanding genetic code expansion tool

The genetic incorporation of the 22(nd) proteinogenic amino acid, pyrolysine (Pyl) at amber codon is achieved by the action of pyrrolysyl-tRNA synthetase (PylRS) together with its cognate tRNA(Pyl). Unlike most aminoacyl-tRNA synthetases, PylRS displays high substrate side chain promiscuity, low sel...

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Bibliographic Details
Main Authors: Wan, Wei, Tharp, Jeffery M., Liu, Wenshe R.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016821/
https://ncbi.nlm.nih.gov/pubmed/24631543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.03.002
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