A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3

Mutations of STAT3 underlie the autosomal dominant form of hyperimmunoglobulin E syndrome (HIES). STAT3 has critical roles in immune cells and thus, hematopoietic stem cell transplantation (HSCT), might be a reasonable therapeutic strategy in this disease. However, STAT3 also has critical functions...

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Autori principali: Steward-Tharp, Scott M., Laurence, Arian, Kanno, Yuka, Kotlyar, Alex, Villarino, Alejandro V., Sciume, Giuseppe, Kuchen, Stefan, Resch, Wolfgang, Wohlfert, Elizabeth A., Jiang, Kan, Hirahara, Kiyoshi, Vahedi, Golnaz, Sun, Hong-wei, Feigenbaum, Lionel, Milner, Joshua D., Holland, Steven M., Casellas, Rafael, Powrie, Fiona, O'Shea, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014840/
https://ncbi.nlm.nih.gov/pubmed/24632714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-09-523167
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