Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

Oncogene-induced reactive oxygen species (ROS) have been proposed to be signaling molecules that mediate proliferative cues. However, ROS may also cause DNA damage and proliferative arrest. How these apparently opposite roles can be reconciled, especially in the context of oncogene-induced cellular...

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Detalhes bibliográficos
Main Authors: Ogrunc, M, Di Micco, R, Liontos, M, Bombardelli, L, Mione, M, Fumagalli, M, Gorgoulis, V G, d'Adda di Fagagna, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013514/
https://ncbi.nlm.nih.gov/pubmed/24583638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.16
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