Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Two major mechanisms have been causally implicated in the establishment of cellular senescence: the activation of the DNA damage response (DDR) pathway and the formation of senescence-associated heterochromatic foci (SAHF). Here we show that in human fibroblasts resistant to premature p16(INK4a) ind...

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Detalhes bibliográficos
Main Authors: Di Micco, Raffaella, Sulli, Gabriele, Dobreva, Miryana, Liontos, Michalis, Botrugno, Oronza A., Gargiulo, Gaetano, Zuffo, Roberto dal, Matti, Valentina, d’Ario, Giovanni, Montani, Erica, Mercurio, Ciro, Hahn, William C., Gorgoulis, Vassilis, Minucci, Saverio, di Fagagna, Fabrizio d’Adda
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918344/
https://ncbi.nlm.nih.gov/pubmed/21336312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2170
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