Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

Oncogene-induced reactive oxygen species (ROS) have been proposed to be signaling molecules that mediate proliferative cues. However, ROS may also cause DNA damage and proliferative arrest. How these apparently opposite roles can be reconciled, especially in the context of oncogene-induced cellular...

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Bibliografske podrobnosti
Main Authors: Ogrunc, M, Di Micco, R, Liontos, M, Bombardelli, L, Mione, M, Fumagalli, M, Gorgoulis, V G, d'Adda di Fagagna, F
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013514/
https://ncbi.nlm.nih.gov/pubmed/24583638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.16
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