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FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity

Hyperactive mammalian target of rapamycin (mTOR) is associated with cognitive deficits in several neurological disorders including tuberous sclerosis complex (TSC). The phosphorylation of the mRNA-binding protein FMRP reportedly depends on mTOR complex 1 (mTORC1) activity via p70 S6 kinase 1 (S6K1)....

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Détails bibliographiques
Auteurs principaux: Bartley, Christopher M., O’Keefe, Rachel A., Bordey, Angélique
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013076/
https://ncbi.nlm.nih.gov/pubmed/24806451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096956
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