Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP

The fragile X mental retardation protein (FMRP) is an mRNA-binding regulator of protein translation that associates with 4-6% of brain transcripts and is central to neurodevelopment. Autism risk genes’ transcripts are overrepresented among FMRP-binding mRNAs, and FMRP loss-of-function mutations are...

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Vydáno v:eNeuro
Hlavní autoři: Bartley, Christopher M., O’Keefe, Rachel A., Blice-Baum, Anna, Mihailescu, Mihaela-Rita, Gong, Xuan, Miyares, Laura, Karaca, Esra, Bordey, Angélique
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2016
Témata:
New Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116651/
https://ncbi.nlm.nih.gov/pubmed/27957526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0092-16.2016
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