Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM. These kinases are stabilized by the TTT (Tel2, Tti1, Tti2) co-chaperone family, whose actions are mediated by CK2 phosphorylation. The inositol p...

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Detalhes bibliográficos
Main Authors: Rao, Feng, Cha, Jiyoung, Xu, Jing, Xu, Risheng, Vandiver, M. Scott, Tyagi, Richa, Tokhunts, Robert, Koldobskiy, Michael A., Fu, Chenglai, Barrow, Roxanne, Wu, Mingxuan, Fiedler, Dorothea, Barrow, James C., Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011022/
https://ncbi.nlm.nih.gov/pubmed/24657168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.02.020
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