Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break

The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are h...

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Bibliografski detalji
Glavni autori: Anderson, Carol M., Korkin, Dmitry, Smith, Dana L., Makovets, Svetlana, Seidel, Jeffrey J., Sali, Andrej, Blackburn, Elizabeth H.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Research Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279195/
https://ncbi.nlm.nih.gov/pubmed/18334620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1646208
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