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Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are h...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279195/ https://ncbi.nlm.nih.gov/pubmed/18334620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1646208 |
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