The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1

AIM: Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt. METHODS: PC12 cells and primary cultured brain neurons of rats were examined. pDC31...

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Autors principals: Wu, Jun-chao, Qi, Lin, Wang, Yan, Kegel, Kimberly B, Yoder, Jennifer, Difiglia, Marian, Qin, Zheng-hong, Lin, Fang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010368/
https://ncbi.nlm.nih.gov/pubmed/22543707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.14
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