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The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
Huntington Disease (HD) is caused by an abnormal expansion of polyQ tract in the protein named huntingtin (Htt). HD pathology is featured by accumulation and aggregation of mutant Htt in striatal and cortical neurons. Aberrant Htt degradation is implicated in HD pathogenesis. The aim of this study w...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469570/ https://ncbi.nlm.nih.gov/pubmed/23071649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046834 |
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