Forward and reverse mouse genetics through derivation of haploid embryonic stem cells

All somatic mammalian cells carry two copies of chromosomes (diploidy), whereas organisms with a single copy of their genome such as yeast provide a basis for recessive genetics. Here we report the generation of haploid mouse ES cell lines from parthenogenetic embryos. These cells carry 20 chromosom...

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Main Authors: Elling, Ulrich, Taubenschmid, Jasmin, Wirnsberger, Gerald, O'Malley, Ronan, Demers, Simon, Vanhaelen, Quentin, Shukalyuk, Andrey I., Schmauss, Gerald, Schramek, Daniel, Schnuetgen, Frank, von Melchner, Harald, Ecker, Joseph R., Stanford, William L., Zuber, Johannes, Stark, Alexander, Penninger, Josef M.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008724/
https://ncbi.nlm.nih.gov/pubmed/22136931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.10.012
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