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Derivation and maintenance of mouse haploid embryonic stem cells

Ploidy represents the number of chromosome sets in a cell. Although gametes have a haploid genome (n), most mammalian cells have diploid genomes (2n). The diploid status of most cells correlates with the number of probable alleles for each autosomal gene and makes it difficult to target these genes...

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Detalhes bibliográficos
Publicado no:Nat Protoc
Main Authors: Elling, Ulrich, Woods, Michael, Forment, Josep V., Fu, Beiyuan, Yang, Fengtang, Ng, Bee Ling, Vicente, Jose R., Adams, David J., Doe, Brendan, Jackson, Stephen P., Penninger, Josef M., Balmus, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997032/
https://ncbi.nlm.nih.gov/pubmed/31160788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-019-0169-z
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